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Br J Cancer. 2014 Feb 4;110(3):797-801. doi: 10.1038/bjc.2013.771. Epub 2013 Dec 10.

Long-term dietary sodium, potassium and fluid intake; exploring potential novel risk factors for renal cell cancer in the Netherlands Cohort Study on diet and cancer.

Author information

1
Department of Epidemiology, School for Oncology and Developmental Biology (GROW), Maastricht University Medical Centre, Peter Debyeplein 1, Maastricht 6229 HA, The Netherlands.
2
Department of Pathology, School for Oncology and Developmental Biology (GROW), Maastricht University Medical Centre, Peter Debyelaan 25, Maastricht 6229 HX, The Netherlands.
3
Division of Medical Oncology, Department of Internal Medicine, School for Oncology and Developmental Biology (GROW), Maastricht University Medical Center, Peter Debyelaan 25, Maastricht 6229 HX, The Netherlands.
4
TNO Quality of Life, Wassenaarseweg 56, Leiden 2333 AL, The Netherlands.

Abstract

BACKGROUND:

As sodium, potassium and fluid intake are related to hypertension, an established risk factor for renal cell cancer (RCC), they may be independent risk factors for RCC.

METHODS:

The Netherlands Cohort Study (NLCS) with case-cohort design included 120,852 participants aged 55-69 years. At baseline, diet and lifestyle were assessed with questionnaires. After 17.3 years of follow-up, 485 RCC cases and 4438 subcohort members were available for analyses.

RESULTS:

Sodium intake increased RCC risk (P-trend=0.03), whereas fluid and potassium intake did not. For high sodium and low fluid intake, the RCC risk additionally increased (P-interaction=0.02).

CONCLUSION:

Sodium intake is a potential risk factor for RCC, particularly if fluid consumption is low.

PMID:
24327014
PMCID:
PMC3915132
DOI:
10.1038/bjc.2013.771
[Indexed for MEDLINE]
Free PMC Article
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