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Arch Med Res. 2014 Jan;45(1):1-14. doi: 10.1016/j.arcmed.2013.11.007. Epub 2013 Dec 8.

Innate immune system cells in atherosclerosis.

Author information

1
Unidad de Investigación Médica en Inmunología, Unidad Médica de Alta Especialidad Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, México, D.F., Mexico.
2
Unidad de Investigación Médica en Inmunología, Unidad Médica de Alta Especialidad Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, México, D.F., Mexico; Departamento de Inmunología, ENCB, IPN, México, D.F., Mexico.
3
Unidad de Investigación Médica en Inmunología, Unidad Médica de Alta Especialidad Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, México, D.F., Mexico. Electronic address: fblanco1@terra.com.mx.

Abstract

Atherosclerosis is a chronic inflammatory disease of the arterial wall characterized by innate and adaptive immune system involvement. A key component of atherosclerotic plaque inflammation is the persistence of different innate immune cell types including mast cells, neutrophils, natural killer cells, monocytes, macrophages and dendritic cells. Several endogenous signals such as oxidized low-density lipoproteins, and exogenous signals such as lipopolysaccharides, trigger the activation of these cells. In particular, these signals orchestrate the early and late inflammatory responses through the secretion of pro-inflammatory cytokines and contribute to plaque evolution through the formation of foam cells, among other events. In this review we discuss how innate immune system cells affect atherosclerosis pathogenesis.

KEYWORDS:

Atherosclerosis; Inflammation; Innate immune system cells

PMID:
24326322
DOI:
10.1016/j.arcmed.2013.11.007
[Indexed for MEDLINE]

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