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Chem Commun (Camb). 2014 May 25;50(40):5301-3. doi: 10.1039/c3cc48473d. Epub 2013 Dec 10.

A small molecule that displays marked reactivity toward copper- versus zinc-amyloid-β implicated in Alzheimer's disease.

Author information

1
Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.

Abstract

Alzheimer's disease (AD) is a complex, multifactorial, neurodegenerative disease that poses tremendous difficulties in pinpointing its precise etiology. A toolkit, which specifically targets and modulates suggested key players, may elucidate their roles in disease onset and progression. We report high-resolution insights on the activity of a small molecule (L2-NO) which exhibits reactivity toward Cu(II)-amyloid-β (Aβ) over Zn(II)-Aβ.

PMID:
24326305
PMCID:
PMC3999264
DOI:
10.1039/c3cc48473d
[Indexed for MEDLINE]
Free PMC Article

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