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Chem Commun (Camb). 2014 Feb 7;50(10):1192-4. doi: 10.1039/c3cc47616b.

High yield and high specific activity synthesis of [18F]fallypride in a batch microfluidic reactor for micro-PET imaging.

Author information

1
Department of Molecular Imaging and Medical Pharmacology, University of California Los Angeles, 570 Westwood Plaza, Los Angeles, USA. pkeng@mednet.ucla.edu.

Abstract

[(18)F]fallypride was synthesized in a batch microfluidic chip with a radiochemical yield of 65 ± 6% (n = 7) and an average specific activity of 730 GBq μmol(-1) (20 Ci μmol(-1)) (n = 4). Specific activity was ~2-fold higher than [(18)F]fallypride synthesized in a macroscale radiosynthesizer, despite starting with significantly less radioactivity, and thus safer conditions, in the microchip.

PMID:
24326303
PMCID:
PMC4479166
DOI:
10.1039/c3cc47616b
[Indexed for MEDLINE]
Free PMC Article

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