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Int J Gynaecol Obstet. 2014 Mar;124(3):230-4. doi: 10.1016/j.ijgo.2013.08.016. Epub 2013 Nov 22.

Endothelial dysfunction after pregnancy-induced hypertension.

Author information

1
Department of Public Health, Federal University of Ceara, Fortaleza, Brazil. Electronic address: anacileiahenriques@gmail.com.
2
Department of Public Health, Federal University of Ceara, Fortaleza, Brazil.
3
Department of Maternal and Child Health, Federal University of Ceara, Fortaleza, Brazil.
4
Medical School, Federal University of Ceara, Fortaleza, Brazil.

Abstract

OBJECTIVE:

To carry out long-term analysis of the presence of endothelial dysfunction after the development of pregnancy-induced hypertension (PIH).

METHODS:

In a retrospective cohort study, data were analyzed from 60 women who delivered at a tertiary maternity hospital in Fortaleza, Ceara, Brazil, between 1992 and 2002. Thirty women had a history of PIH and 30 had no history of complications. Anthropometric and laboratory data were collected, and endothelial function was evaluated by flow-mediated dilatation of the brachial artery. Continuous variables were analyzed via Student t test, and Mann-Whitney test was used to compare means. Clinical and metabolic measures were categorized according to cardiovascular risk by cutoff points determined by national consensus; χ2 and Fisher exact tests were used to compare the groups. Relative risk was calculated for variables that were statistically significant (P<0.05).

RESULTS:

Women with a history of PIH had higher body mass index (P=0.03), systolic blood pressure (P=0.03), low-density lipoprotein cholesterol (P=0.02), and fasting glucose (P=0.02) compared with women with no pregnancy complications. The frequency of endothelial dysfunction was 60% among all women, with a significant difference between the 2 groups (P=0.01).

CONCLUSION:

Women with a history of PIH were found to have a higher frequency of long-term endothelial dysfunction.

KEYWORDS:

Hypertension; Pre-eclampsia; Pregnancy-induced; Vascular endothelium

PMID:
24326066
DOI:
10.1016/j.ijgo.2013.08.016
[Indexed for MEDLINE]
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