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J Infect Dis. 2014 May 15;209(10):1623-7. doi: 10.1093/infdis/jit807. Epub 2013 Dec 10.

Toll-like receptor polymorphism associations with HIV-1 outcomes among sub-Saharan Africans.

Author information

1
Department of Global Health.

Abstract

OBJECTIVE:

We evaluated Toll-like receptors (TLRs) single nucleotide polymorphisms (SNPs) for associations with HIV-1 acquisition, set-point and disease progression in African couples.

METHODS:

Seven candidate and 116 haplotype-tagging SNPs (tagSNPs) were genotyped in 504 HIV-1 infected cases, and 343 seronegative controls.

RESULTS:

TLR9 1635A/G was associated with reduced HIV-1 acquisition among HIV-seronegative controls with high but not low HIV-1 exposure (odds ratio [OR] = 0.7; P = .03 and OR = 0.9, P = .5, respectively). TLR7 rs179012 and TLR2 597C/T reduced set-point; the latter modified by time since HIV-1 acquisition. TLR8 1A/G reduced disease progression.

CONCLUSIONS:

TLR SNPs impact HIV-1 outcomes with epidemiologic factors modifying these relationships.

KEYWORDS:

Acute Infection; Genetics; HIV-1 acquisition; HIV-1 set-point; Heterosexual HIV-1 transmission; Progression; Risk Factors; Toll-like Receptors; Viral load

PMID:
24325963
PMCID:
PMC3997584
DOI:
10.1093/infdis/jit807
[Indexed for MEDLINE]
Free PMC Article

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