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Tuberculosis (Edinb). 2014 Mar;94(2):159-61. doi: 10.1016/j.tube.2013.03.004. Epub 2013 Dec 8.

Molecular characteristics of MDR Mycobacterium tuberculosis strains isolated in Fujian, China.

Author information

1
Fujian Center for Disease Control and Prevention, Fujian, China.
2
National Center for Tuberculosis Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
3
Fujian Center for Disease Control and Prevention, Fujian, China. Electronic address: Zhjf_8888@126.com.
4
Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China; Beijing Chest Hospital, Capital Medical University, Beijing, China. Electronic address: suhuazheng342@sohu.com.

Abstract

Of 75 MDR isolates from Fujian Province, the sensitivity of RIF, INH, EMB, SM, OFLX and KAN resistance by DNA sequencing was 96.0%, 96.0%, 66.7%, 66.0%, 84.2% and 75.0%, respectively. We also identified that minority mutations in the mixed Mycobacterium tuberculosis population may be responsible for two "false-negative" results. In addition, Beijing genotype is still the predominant sublineage in the MDR TB cases from Fujian.

KEYWORDS:

MDR; Molecular characteristics; Mycobacterium tuberculosis

PMID:
24325872
DOI:
10.1016/j.tube.2013.03.004
[Indexed for MEDLINE]

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