Format

Send to

Choose Destination
Front Oncol. 2013 Nov 26;3:289. doi: 10.3389/fonc.2013.00289. eCollection 2013.

Feasibility of tomotherapy-based image-guided radiotherapy for small cell lung cancer.

Author information

1
Department of Radiation Oncology, University of Arizona , Tucson, AZ , USA.

Abstract

BACKGROUND:

To assess the tolerance of patients with small cell lung cancer undergoing chemoradiation with tomotherapy-based image-guided radiotherapy (IGRT).

MATERIALS AND METHODS:

A retrospective review of the toxicity profile for nine patients with small cell lung cancer of the limited stage who underwent chemoradiation delivered with helical tomotherapy (HT) has been conducted.

RESULTS:

Acute grade 3-4 hematologic and esophagitis toxicities developed in two and three patients respectively. One patient developed a pulmonary embolism during radiotherapy. Seven patients had weight loss ranging from 0 to 30 pounds (median: 4 pounds). Three patients had treatment breaks ranging from 2 to 12 days. At a median follow-up of 11 months (range: 2-24 months), no patients developed any radiation related toxicities such as grade 3-4 pneumonitis or other long-term complications. The median survival was estimated to be 15 months. There were two local recurrences, three mediastinal recurrences, and six distant metastases.

CONCLUSION:

Grade 3-4 toxicities remained significant during chemoradiation when radiation was delivered with tomotherapy-based IGRT. However, the absence of grade 3-4 pneumonitis is promising and the use of HT needs to be investigated in future prospective studies.

KEYWORDS:

IGRT; chemoradiation; limited stage; small cell lung cancer

Supplemental Content

Full text links

Icon for Frontiers Media SA Icon for PubMed Central
Loading ...
Support Center