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J Biol Chem. 2014 Jan 17;289(3):1203-11. doi: 10.1074/jbc.R113.534743. Epub 2013 Dec 9.

Unfolded protein response signaling and metabolic diseases.

Author information

1
From the Division of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115.

Abstract

The endoplasmic reticulum (ER) is a central organelle for protein biosynthesis, folding, and traffic. Perturbations in ER homeostasis create a condition termed ER stress and lead to activation of the complex signaling cascade called the unfolded protein response (UPR). Recent studies have documented that the UPR coordinates multiple signaling pathways and controls various physiologies in cells and the whole organism. Furthermore, unresolved ER stress has been implicated in a variety of metabolic disorders, such as obesity and type 2 diabetes. Therefore, intervening in ER stress and modulating signaling components of the UPR would provide promising therapeutics for the treatment of human metabolic diseases.

KEYWORDS:

Diabetes; ER Stress; Metabolic Diseases; Obesity; Unfolded Protein Response

PMID:
24324257
PMCID:
PMC3894306
DOI:
10.1074/jbc.R113.534743
[Indexed for MEDLINE]
Free PMC Article

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