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Cereb Cortex. 2015 May;25(5):1362-78. doi: 10.1093/cercor/bht328. Epub 2013 Dec 8.

Auditory responses and stimulus-specific adaptation in rat auditory cortex are preserved across NREM and REM sleep.

Author information

1
Department of Psychiatry, University of Wisconsin-Madison, Madison, WI 53719, USA Department of Physiology and Pharmacology, Sackler School of Medicine, and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv 69978, Israel.
2
Department of Psychiatry, University of Wisconsin-Madison, Madison, WI 53719, USA Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, UK.
3
Department of Psychiatry, University of Wisconsin-Madison, Madison, WI 53719, USA.
4
Department of Anesthesiology, University of Wisconsin, Madison, WI 53706, USA.

Abstract

Sleep entails a disconnection from the external environment. By and large, sensory stimuli do not trigger behavioral responses and are not consciously perceived as they usually are in wakefulness. Traditionally, sleep disconnection was ascribed to a thalamic "gate," which would prevent signal propagation along ascending sensory pathways to primary cortical areas. Here, we compared single-unit and LFP responses in core auditory cortex as freely moving rats spontaneously switched between wakefulness and sleep states. Despite robust differences in baseline neuronal activity, both the selectivity and the magnitude of auditory-evoked responses were comparable across wakefulness, Nonrapid eye movement (NREM) and rapid eye movement (REM) sleep (pairwise differences <8% between states). The processing of deviant tones was also compared in sleep and wakefulness using an oddball paradigm. Robust stimulus-specific adaptation (SSA) was observed following the onset of repetitive tones, and the strength of SSA effects (13-20%) was comparable across vigilance states. Thus, responses in core auditory cortex are preserved across sleep states, suggesting that evoked activity in primary sensory cortices is driven by external physical stimuli with little modulation by vigilance state. We suggest that sensory disconnection during sleep occurs at a stage later than primary sensory areas.

KEYWORDS:

NREM sleep; REM sleep; auditory cortex; oddball; rat; single unit

PMID:
24323498
PMCID:
PMC4415088
DOI:
10.1093/cercor/bht328
[Indexed for MEDLINE]
Free PMC Article
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