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Proteomics Clin Appl. 2013 Dec;7(11-12):748-55. doi: 10.1002/prca.201300041.

On best practices: the Institute of Medicine scheme for developing, validating, and demonstrating clinical utility of omics-based diagnostic and predictive tests.

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Departments of Computational Medicine and Bioinformatics, Internal Medicine, and Human Genetics, School of Public Health, University of Michigan, Ann Arbor, MI, USA; Institute for Systems Biology, Seattle, WA, USA.


The Institute of Medicine of the US National Academy of Sciences issued a major report in 2012 that provides important guidance for the proteomics community for credible and transparent development of all kinds of omics-based diagnostic and prognostic tests. The key elements are summarized here to provide a compass that can guide the studies emerging from many laboratories as reported in this special issue of Proteomics Clinical Applications on "Diagnostic Proteomics."


Diagnostics; Institute of Medicine; Omics; Tests

[Indexed for MEDLINE]

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