A pyrene derivative for Hg(2+) -selective fluorescent sensing and its application in in vivo imaging

Chem Asian J. 2014 Mar;9(3):744-8. doi: 10.1002/asia.201301123. Epub 2013 Dec 9.

Abstract

An Hg(2+) -selective fluorescent sensor (1) bearing pyrene as a fluorophore was synthesized. A sandwich-stacking binding mode was formed during the binding process, which increased the excimer fluorescence 22-fold at 490 nm. Compound 1 was successfully applied in in vivo imaging to trace the enrichment and distribution of mercury in the nervous system, digestive system, and reproductive system of Caenorhabditis elegans, as well as the organs of zebrafish.

Keywords: fluorescent probes; in vivo imaging; mercury; molecular recognition; sensors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Caenorhabditis elegans / anatomy & histology
  • Caenorhabditis elegans / chemistry
  • Caenorhabditis elegans / metabolism
  • Fluorescent Dyes / analysis*
  • Fluorescent Dyes / chemical synthesis*
  • Fluorescent Dyes / chemistry
  • Mercury / analysis*
  • Molecular Structure
  • Pyrenes / chemical synthesis
  • Pyrenes / chemistry*
  • Zebrafish / anatomy & histology
  • Zebrafish / metabolism

Substances

  • Fluorescent Dyes
  • Pyrenes
  • pyrene
  • Mercury