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Cornea. 2014 Feb;33(2):145-7. doi: 10.1097/ICO.0000000000000027.

Relationship between IL1β-511C>T and ILRN VNTR polymorphisms and keratoconus.

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  • 1Departments of *Ophthalmology and †Medical Genetics, Ege University Faculty of Medicine, Izmir, Turkey.

Abstract

PURPOSE:

The aim of this study was to evaluate the relationship between keratoconus (KC) and interleukin-1β (IL1 β) (-511C>T) and interleukin-1 receptor antagonist (IL1RN) variable number of tandem repeat (VNTR) polymorphisms that are potentially associated in their genetic susceptibility to KC.

METHODS:

A total of 121 patients with KC and 121 healthy individuals were enrolled. Blood samples with ethylenediamine tetraacetic acid were obtained, and IL1β (-511C>T) (rs16944) (polymerase chain reaction-restriction fragment length polymorphism method) and IL1RN VNTR polymorphisms (rs2234663) (polymerase chain reaction and agarose gel imaging) were investigated.

RESULTS:

Genotype and allele distribution for IL1β (-511C>T) and IL1RN VNTR polymorphisms among the KC and healthy groups showed no difference (for all; P > 0.05).

CONCLUSIONS:

Because the genotype and allele frequency of both polymorphisms are identical, it is most likely that IL1β-511C>T and IL1RN VNTR polymorphisms do not play a role in the development of KC in the Turkish population.

PMID:
24322806
DOI:
10.1097/ICO.0000000000000027
[PubMed - indexed for MEDLINE]
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