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AIDS. 2014 Jan 28;28(3):439-42. doi: 10.1097/QAD.0000000000000166.

A comparison of methods for measuring rectal HIV levels suggests that HIV DNA resides in cells other than CD4+ T cells, including myeloid cells.

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1
aSan Francisco Veterans Affairs Medical Center bUniversity of California, San Francisco (UCSF), California, USA.

Abstract

We compared different techniques for measuring gut HIV reservoirs and assessed for HIV in non-CD4 T cells. HIV DNA levels were similar when measured from rectal biopsies and isolated rectal cells, while HIV RNA tended to be higher in rectal cells. HIV DNA levels in total rectal cells were greater than those predicted from levels in sorted CD4 T cells, suggesting a reservoir in non-CD4 T cells, and HIV DNA was detected in sorted myeloid cells (7/7 subjects).

PMID:
24322272
PMCID:
PMC4130176
DOI:
10.1097/QAD.0000000000000166
[Indexed for MEDLINE]
Free PMC Article
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