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J Acquir Immune Defic Syndr. 2014 Jan 1;65 Suppl 1:S19-23. doi: 10.1097/QAI.0000000000000035.

Optimizing the protection of research participants and personnel in HIV-related research where TB is prevalent: practical solutions for improving infection control.

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  • 1*Johns Hopkins University School of Nursing, Department of Community and Public Health, Baltimore, MD; †Johns Hopkins Center for AIDS Research (CFAR), Baltimore, MD; ‡The Ohio State University College of Nursing, Columbus, OH; §National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, MD; ‖Division of Global HIV/AIDS (GAP), Centers for Disease Control and Prevention, Atlanta, GA; ¶Johns Hopkins Berman Institute of Bioethics; and #Johns Hopkins University School of Medicine, Baltimore, MD.


Tuberculosis (TB) is a leading cause of death among persons with HIV globally. HIV-related research in TB endemic areas raises some unique and important ethical issues in infection control related to protecting both research participants and personnel. To address such concerns, this article provides practical guidance to help research teams develop strategies to prevent TB transmission in studies involving persons with HIV in TB endemic settings.

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