Format

Send to

Choose Destination
See comment in PubMed Commons below
Int J Infect Dis. 2014 Feb;19:100-2. doi: 10.1016/j.ijid.2013.10.019. Epub 2013 Dec 7.

Mannose-binding lectin genetic analysis: possible protective role of the HYPA haplotype in the development of recurrent urinary tract infections in men.

Author information

1
Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università di Napoli Federico II, Napoli, Italy; CEINGE-Biotecnologie Avanzate, Napoli, Italy. Electronic address: olga.scudiero@unina.it.
2
CEINGE-Biotecnologie Avanzate, Napoli, Italy; IRCCS-Fondazione SDN, Napoli, Italy.
3
Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università di Napoli Federico II, Napoli, Italy; CEINGE-Biotecnologie Avanzate, Napoli, Italy.
4
Dipartimento di Medicina e Chirurgia, Catterdra di Ginecologia e Ostetricia, Università degli Studi di Salerno, Salerno, Italy.
5
Dipartimento di Scienze Ostetriche e Ginecologiche, Università degli Studi di Napoli Federico II, Napoli, Italy.
6
Dipartimento di Neuroscienze, Scienze Riproduttive e Odontostomatologiche, Università degli Studi di Napoli Federico II, Napoli, Italy.
7
Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università di Napoli Federico II, Napoli, Italy; CEINGE-Biotecnologie Avanzate, Napoli, Italy; Dipartimento di Scienze e Tecnologie Ambientali Biologiche Farmaceutiche, Seconda Università degli Studi di Napoli, Caserta, Italy.

Abstract

Factors related to bacterial virulence and/or to the host have been implicated in the pathogenesis of recurrent urinary tract infections (rUTI), but in most cases the cause is unknown. Mannose binding lectin (MBL) is an acute phase glycoprotein that exerts immunological functions by binding to the surface of a variety of pathogens. Some human gene variants reduce MBL activity thereby predisposing the host to bacterial and viral infections. The aim of this study was to investigate MBL2 gene variants in relation to rUTI risk. Six MBL gene variants and seven haplotypes were analyzed by PCR and direct sequencing in rUTI patients (n = 83) and in healthy subjects from southern Italy (n = 642). The frequencies of the L allele (-550) and the HYPA haplotype were higher in controls than in patients stratified according to sex (p < 0.05). Our data indicate that the HYPA haplotype in the MBL2 gene could be associated with a minor risk of developing rUTI in males.

KEYWORDS:

Haplotype; MBL; Molecular analysis; rUTI

PMID:
24321858
DOI:
10.1016/j.ijid.2013.10.019
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center