HIV integrase and the swan song of the CD4 T cells?

Retrovirology. 2013 Dec 9:10:149. doi: 10.1186/1742-4690-10-149.

Abstract

T cell apoptosis represents one pathophysiological mechanism associated with AIDS. Herein, we discuss the recent report published by A. Cooper et al. in Nature (June 2013) regarding HIV viral DNA integration-mediated apoptosis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • CD4-Positive T-Lymphocytes / pathology*
  • CD4-Positive T-Lymphocytes / virology*
  • DNA Damage*
  • DNA-Activated Protein Kinase / metabolism*
  • HIV-1 / pathogenicity*
  • Humans
  • Proviruses / pathogenicity*
  • Virus Integration*

Substances

  • DNA-Activated Protein Kinase