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BMC Genomics. 2013 Dec 10;14:867. doi: 10.1186/1471-2164-14-867.

Association of homocysteine with type 2 diabetes: a meta-analysis implementing Mendelian randomization approach.

Author information

1
Department of Food Science and Nutrition, Zhejiang University, 268 Kaixuan Road, Hangzhou 310029, China. duoli@zju.edu.cn.

Abstract

BACKGROUND:

We tested the hypothesis that elevated homocysteine (Hcy) level is causally associated with increased risk of type 2 diabetes mellitus (T2DM).

RESULTS:

The meta-analysis and Mendelian randomization analysis were performed among 4011 cases and 4303 controls. The absolute pooled mean Hcy concentration in subjects with MTHFR 677TT was 5.55 μmol/L (95% CI, 1.33 to 9.77) greater than that in subjects with MTHFR 677CC in T2DM. Overall, the T allele of the MTHFR 677 C > T conferred a greater risk for T2DM [Random effect (RE) OR = 1.31(1.17-1.64), I² = 41.0%, p = 0.055]. The random effect (RE) pooled OR associated with T2DM for MTHFR 677TT relative to the 677CC was [RE OR = 1.38(1.18-1.62)]. The fixed-effect pooled OR of the association for the MTHFR 677 TT vs CT was 1.29 (95% CI, 1.09-1.51). MTHFR 677 TT showed a significantly higher risk for T2DM compared with MTHFR 677 CC + CT [Fixed effect (FE) OR = 1.32(1.14-1.54), I² = 0.0%, p = 0.686]. The absolute pooled mean Hcy concentration in individuals with T2DM was 0.94 μmol/L (95% CI, 0.40-1.48) greater than that in control subjects. The estimated causal OR associated with T2DM was 1.29 for 5 μmol/L increment in Hcy.

CONCLUSIONS:

Our findings provided strong evidence on the causal association of Hcy level with the development of T2DM.

PMID:
24320691
PMCID:
PMC3878883
DOI:
10.1186/1471-2164-14-867
[Indexed for MEDLINE]
Free PMC Article

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