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Nat Neurosci. 2014 Jan;17(1):131-43. doi: 10.1038/nn.3599. Epub 2013 Dec 8.

Identification of a unique TGF-β-dependent molecular and functional signature in microglia.

Author information

1
Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
2
Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA.
3
Neuroimmunology Unit, Montréal Neurological Institute, McGill University, Montréal, Québec, Canada.
4
Department of Immunology, Cleveland Clinic, Cleveland, Ohio, USA.
5
Brain Science Institute and Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA.

Erratum in

  • Nat Neurosci. 2014 Sep;17(9):1286.

Abstract

Microglia are myeloid cells of the CNS that participate both in normal CNS function and in disease. We investigated the molecular signature of microglia and identified 239 genes and 8 microRNAs that were uniquely or highly expressed in microglia versus myeloid and other immune cells. Of the 239 genes, 106 were enriched in microglia as compared with astrocytes, oligodendrocytes and neurons. This microglia signature was not observed in microglial lines or in monocytes recruited to the CNS, and was also observed in human microglia. We found that TGF-β was required for the in vitro development of microglia that express the microglial molecular signature characteristic of adult microglia and that microglia were absent in the CNS of TGF-β1-deficient mice. Our results identify a unique microglial signature that is dependent on TGF-β signaling and provide insights into microglial biology and the possibility of targeting microglia for the treatment of CNS disease.

PMID:
24316888
PMCID:
PMC4066672
DOI:
10.1038/nn.3599
[Indexed for MEDLINE]
Free PMC Article

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