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Semin Cancer Biol. 2014 Jun;26:89-98. doi: 10.1016/j.semcancer.2013.11.003. Epub 2013 Dec 6.

HTLV-1 clonality in adult T-cell leukaemia and non-malignant HTLV-1 infection.

Author information

1
Section of Immunology, Imperial College, London W2 1PG, UK. Electronic address: c.bangham@imperial.ac.uk.
2
Section of Immunology, Imperial College, London W2 1PG, UK.

Abstract

Human T lymphotropic virus type 1 (HTLV-1) causes a range of chronic inflammatory diseases and an aggressive malignancy of T lymphocytes known as adult T-cell leukaemia/lymphoma (ATLL). A cardinal feature of HTLV-1 infection is the presence of expanded clones of HTLV-1-infected T cells, which may persist for decades. A high viral burden (proviral load) is associated with both the inflammatory and malignant diseases caused by HTLV-1, and it has been believed that the oligoclonal expansion of infected cells predisposes to these diseases. However, it is not understood what regulates the clonality of HTLV-1 in vivo, that is, the number and abundance of HTLV-1-infected T cell clones. We review recent advances in the understanding of HTLV-1 infection and disease that have come from high-throughput quantification and analysis of HTLV-1 clonality in natural infection.

KEYWORDS:

Clonality; HTLV-1; High-throughput sequencing; Integration; Leukaemia; Lymphoma; Persistent infection; Retrovirus

PMID:
24316494
PMCID:
PMC4062949
DOI:
10.1016/j.semcancer.2013.11.003
[Indexed for MEDLINE]
Free PMC Article

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