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Cell. 2013 Dec 5;155(6):1207-8. doi: 10.1016/j.cell.2013.11.018.

Structure modeling using genetically engineered crosslinking.

Author information

1
Laboratory of Structural Sciences, Center for Structural Biology and Drug Discovery, Van Andel Research Institute, 333 Bostwick Avenue NE, Grand Rapids, MI 49503, USA.

Abstract

Class B G-protein-coupled receptors are exciting drug targets, yet the structure of a complete receptor bound to a peptide agonist has remained elusive. Coin et al. present a model of the receptor CRF1R bound to its native ligand based on partial structures and 44 spatial constraints revealed by new crosslinking approaches.

PMID:
24315089
DOI:
10.1016/j.cell.2013.11.018
[Indexed for MEDLINE]
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