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Epilepsy Res. 2014 Feb;108(2):280-8. doi: 10.1016/j.eplepsyres.2013.11.006. Epub 2013 Nov 18.

Clinical value of magnetoencephalographic spike propagation represented by spatiotemporal source analysis: correlation with surgical outcome.

Author information

1
Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 Thirteenth Street, Suite 2301, Charlestown, MA 02129, USA. Electronic address: naoro@nmr.mgh.harvard.edu.
2
Division of Epilepsy and Clinical Neurophysiology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA.
3
Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 Thirteenth Street, Suite 2301, Charlestown, MA 02129, USA.
4
Department of Neurosurgery, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA.
5
Department of Neurology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.

Abstract

OBJECTIVE:

To investigate the correlation between spike propagation represented by spatiotemporal source analysis of magnetoencephalographic (MEG) spikes and surgical outcome in patients with temporal lobe epilepsy.

METHODS:

Thirty-seven patients were divided into mesial (n=27) and non-mesial (n=10) groups based on the presurgical evaluation. In each patient, ten ipsilateral spikes were averaged, and spatiotemporal source maps of the averaged spike were obtained by using minimum norm estimate. Regions of interest (ROIs) were created including temporoparietal, inferior frontal, mesial temporal, anterior and posterior part of the lateral temporal cortex. We extracted activation values from the source maps and the threshold was set at half of the maximum activation at the peak latency. The leading and propagated areas of the spike were defined as those ROIs with activation reaching the threshold at the earliest and at the peak latencies, respectively. Surgical outcome was assessed based on Engel's classification. Binary variables were created from leading areas (restricted to the anterior and mesial temporal ROIs or not) and from propagation areas (involving the temporoparietal ROI or not), and for surgical outcome (Class I or not). Fisher's exact test was used for significance testing.

RESULTS:

In total and mesial group, restricted anterior/mesial temporal leading areas were correlated with Class I (p<0.05). Temporoparietal propagation was correlated with Class II-IV (p<0.05). For the non-mesial group, no significant relation was found.

CONCLUSIONS:

Spike propagation patterns represented by spatiotemporal source analysis of MEG spikes may provide useful information for prognostic implication in presurgical evaluation of epilepsy.

KEYWORDS:

Epilepsy surgery; Magnetoencephalography (MEG); Minimum norm estimate (MNE); Spike propagation; Temporal lobe epilepsy

PMID:
24315019
PMCID:
PMC3933022
DOI:
10.1016/j.eplepsyres.2013.11.006
[Indexed for MEDLINE]
Free PMC Article

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