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J Pediatr Surg. 2013 Dec;48(12):2373-7. doi: 10.1016/j.jpedsurg.2013.08.009.

The most reliable early predictors of outcome in patients with biliary atresia after Kasai's operation.

Author information

1
Department of Pediatric Surgery, Osaka Medical Center and Research Institute for Maternal and Child Health, 840 Murodo-cho Izumi, Osaka, 594-1101, Japan. Electronic address: tgoda@mch.pref.osaka.jp.

Abstract

BACKGROUND/PURPOSE:

The purpose of this study was to determine reliable predictors of outcome of biliary atresia (BA) after Kasai's operation.

PATIENTS AND METHODS:

Fifty-four BA cases that underwent Kasai's operation at our institution over two decades were reviewed. The cases were divided into two groups: Group I: cases that required liver transplantation or died (n=30) and Group II: cases alive with the native liver. Serum levels of total bilirubin (TB), direct bilirubin (DB), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and gamma-glutamyltransferase (GGT) were measured sequentially after surgery. For cut-off determination, receiver operating characteristic (ROC) analysis was employed.

RESULTS:

Serum TB, DB, AST, and ALT in Group I were significantly higher than those in Group II at 1, 2, and 3 months after surgery (p<.05). The most reliable cut-offs determined by ROC analysis were DB of 0.7 mg/dl at 2 months (sensitivity; 93%, specificity; 75%) and AST of 94 IU/L at 2 months (sensitivity; 87%, specificity; 71%). The 54 cases were re-divided into three groups according to the cut-off values: group G (good) with DB and AST<cut-offs (n=16; Group I:II=1:15), group M (moderate) with DB or AST>cut-offs (n=9; Group I:II=4:5), and group P (poor) with DB and AST ≥ cut-offs (n=29; Group I:II=25:4). The 15-year survival rate in groups G, M, and P was 94%, 44%, and 22%, respectively (p<.001).

CONCLUSION:

The combination of serum DB and AST at 2 months after Kasai's operation is a reliable predictor of long-term BA outcome.

KEYWORDS:

AST; Biliary atresia; Direct bilirubin; Predictor; Prognosis

PMID:
24314173
DOI:
10.1016/j.jpedsurg.2013.08.009
[Indexed for MEDLINE]

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