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Science. 2013 Dec 6;342(6163):1243-6. doi: 10.1126/science.1243364.

Nonredundant function of soluble LTα3 produced by innate lymphoid cells in intestinal homeostasis.

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1
German Rheumatism Research Center (DRFZ), a Leibniz Institute, Berlin 10117, Germany.

Abstract

Immunoglobulin A (IgA) production at mucosal surfaces contributes to protection against pathogens and controls intestinal microbiota composition. However, mechanisms regulating IgA induction are not completely defined. We show that soluble lymphotoxin α (sLTα3) produced by RORγt(+) innate lymphoid cells (ILCs) controls T cell-dependent IgA induction in the lamina propria via regulation of T cell homing to the gut. By contrast, membrane-bound lymphotoxin β (LTα1β2) produced by RORγt(+) ILCs is critical for T cell-independent IgA induction in the lamina propria via control of dendritic cell functions. Ablation of LTα in RORγt(+) cells abrogated IgA production in the gut and altered microbiota composition. Thus, soluble and membrane-bound lymphotoxins produced by ILCs distinctly organize adaptive immune responses in the gut and control commensal microbiota composition.

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PMID:
24311691
DOI:
10.1126/science.1243364
[Indexed for MEDLINE]
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