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Pediatr Obes. 2014 Jun;9(3):e68-72. doi: 10.1111/j.2047-6310.2013.00200.x. Epub 2013 Dec 5.

Newborns with lower levels of circulating polyunsaturated fatty acids (PUFA) are abdominally more adipose.

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  • 1Endocrinology Unit, Hospital Sant Joan de Déu, University of Barcelona, Esplugues, Barcelona, Spain.

Abstract

BACKGROUND:

Maternal nutrition is the main source of Poly-Unsaturated Fatty Acids (PUFA) for the fetus. PUFA may influence the accumulation of fat in early life.

OBJECTIVES & METHODS:

In 33 breastfed infants born appropriate-for-gestational-age, we studied whether body composition (judged by absorptiometry at 2 wk and 4 mo) relates to PUFA levels (assessed by gas chromatography) in the maternal or fetal circulation at birth.

RESULTS:

Abdominal fat at 2 wk associated negatively to umbilical-cord levels of separate PUFA (linoleic, arachidonic, eicosapentanoic and docosahexaenoic acid; all P between 0.001 and 0.015). Collectively, the assessed n-6 PUFA on one hand and the n-3 PUFA on the other hand associated negatively to the absolute amount of abdominal fat (in grams; P = 0.001 and P = 0.002, respectively) and to the relative amount of abdominal fat (fraction of total fat; P = 0.001 and P = 0.006, respectively). No other significant associations were observed.

CONCLUSION:

In conclusion, newborns with lower levels of circulating PUFA were found to be abdominally more adipose. The mechanisms underpinning these associations remain to be determined.

KEYWORDS:

Abdominal fat; absorptiometry; maternal nutrition; polyunsaturated fatty acids

[PubMed - indexed for MEDLINE]
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