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J Mol Med (Berl). 2014 Jan;92(1):13-30. doi: 10.1007/s00109-013-1109-y. Epub 2013 Dec 6.

Metastasis suppressors in breast cancers: mechanistic insights and clinical potential.

Author information

1
Department of Cancer Biology The University of Kansas Medical Center, Kansas City, KS 66160, USA.
#
Contributed equally

Abstract

For the most part, normal epithelial cells do not disseminate to other parts of the body and proliferate, as do metastatic cells. Presumably, a class of molecules-termed metastasis suppressors-are involved in this homeostatic control. Metastasis suppressors are, by definition, cellular factors that, when re-expressed in metastatic cells, functionally inhibit metastasis without significantly inhibiting tumor growth. In this brief review, we catalog known metastasis suppressors, what is known about their mechanism(s) of action, and experimental and clinical associations to date.

PMID:
24311119
PMCID:
PMC3923422
DOI:
10.1007/s00109-013-1109-y
[Indexed for MEDLINE]
Free PMC Article

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