Format

Send to

Choose Destination
Arch Immunol Ther Exp (Warsz). 2014 Jun;62(3):187-94. doi: 10.1007/s00005-013-0267-5. Epub 2013 Dec 6.

Monocytes in sterile inflammation: recruitment and functional consequences.

Author information

1
Department of Surgery, Washington University in St. Louis, St. Louis, MO, USA.

Abstract

Monocytes play an important role in initiating innate immune responses. Three subsets of these cells have been defined in mice including classical, nonclassical and intermediate monocytes. Each of these cell types has been extensively studied for their role in infectious diseases. However, their role in sterile injury as occurs during ischemia-reperfusion injury, atherosclerosis, and trauma has only recently been the focus of investigations. Here, we review mechanisms of monocyte recruitment to sites of sterile injury, their modes of action, and their effect on disease outcome in murine models with some references to human studies. Therapeutic strategies to target these cells must be developed with caution since each monocyte subset is capable of mediating either anti- or pro-inflammatory effects depending on the setting.

PMID:
24310705
PMCID:
PMC4294530
DOI:
10.1007/s00005-013-0267-5
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Springer Icon for PubMed Central
Loading ...
Support Center