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Skin Therapy Lett. 2013 Jun;18(4):1-4.

Selected skin diseases with systemic involvement.

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Department of Dermatology, Hospital Clínico Universidad de Chile, Santiago, Chile; Department of Dermatology, Cleveland Clinic, Cleveland, OH, USA.


The skin is often a window to systemic disease that is available to the trained eye of the dermatologist. Herein, we focus on four dermatoses with associated systemic conditions of interest: scleromyxedema and monoclonal gammopathy, nephrogenic systemic fibrosis in the setting of renal insufficiency, dermatitis herpetiformis and celiac disease, and psoriasis as a risk factor for cardiovascular disease. Dermatologists can play a crucial role in recognizing the cutaneous manifestations linked with these conditions. Identifying the related underlying disorder will contribute to appropriate diagnosis and improved management.

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