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Mol Cell Proteomics. 2014 Feb;13(2):397-406. doi: 10.1074/mcp.M113.035600. Epub 2013 Dec 5.

Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics.

Author information

1
Science for Life Laboratory, KTH - Royal Institute of Technology, SE-171 21 Stockholm, Sweden;

Abstract

Global classification of the human proteins with regards to spatial expression patterns across organs and tissues is important for studies of human biology and disease. Here, we used a quantitative transcriptomics analysis (RNA-Seq) to classify the tissue-specific expression of genes across a representative set of all major human organs and tissues and combined this analysis with antibody-based profiling of the same tissues. To present the data, we launch a new version of the Human Protein Atlas that integrates RNA and protein expression data corresponding to ∼80% of the human protein-coding genes with access to the primary data for both the RNA and the protein analysis on an individual gene level. We present a classification of all human protein-coding genes with regards to tissue-specificity and spatial expression pattern. The integrative human expression map can be used as a starting point to explore the molecular constituents of the human body.

PMID:
24309898
PMCID:
PMC3916642
DOI:
10.1074/mcp.M113.035600
[Indexed for MEDLINE]
Free PMC Article

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