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J Pediatr Hematol Oncol. 2014 Nov;36(8):e536-9. doi: 10.1097/MPH.0000000000000063.

Glioblastoma multiforme arising from dysembryoplastic neuroepithelial tumor in a child in the absence of therapy.

Author information

1
Departments of *Radiology †Pediatrics ‡Pathology §Neurosciences, San Diego and Rady Children's Hospital, University of California, San Diego, CA.

Abstract

Dysembryoplastic neuroepithelial tumors (DNETs) are considered as low-grade tumors commonly associated with intractable seizures. We report a case of an unusual hemispheric DNET in a young child presenting with new-onset focal seizures. The tumor was notable for its atypical neuroimaging features and very rapid malignant transformation into a glioblastoma multiforme in the absence of radiation or chemotherapy, 1-year postdiagnosis. Our case highlights the malignant potential of atypical DNETs in the absence of therapy.

PMID:
24309599
DOI:
10.1097/MPH.0000000000000063
[Indexed for MEDLINE]

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