Format

Send to

Choose Destination
See comment in PubMed Commons below
Trends Immunol. 2014 Feb;35(2):88-93. doi: 10.1016/j.it.2013.10.010. Epub 2013 Dec 2.

STING-dependent cytosolic DNA sensing pathways.

Author information

1
Department of Cell Biology and Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA. Electronic address: gbarber@med.miami.edu.

Abstract

STING (STimulator of INterferon Genes) has recently been identified as being essential for controlling host defense countermeasures triggered by microbial cytosolic DNA and subsequently cyclic dinucleotides (CDNs). However, chronic STING activation may also be responsible for initiating certain inflammatory diseases manifested by self DNA. Recent studies have also revealed a key role for cyclic GMP-AMP synthase (cGAS) in STING activation. Although a full understanding of the mechanisms of STING activation requires further studies, new insights into STING function afford the opportunity of designing novel compounds aimed at facilitating vaccine development or new therapies for the treatment of inflammatory disease.

KEYWORDS:

STING; cytosolic DNA; inflammation; interferon

PMID:
24309426
DOI:
10.1016/j.it.2013.10.010
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center