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Cell Signal. 2014 Mar;26(3):556-63. doi: 10.1016/j.cellsig.2013.11.026. Epub 2013 Dec 2.

HDAC4 protects cells from ER stress induced apoptosis through interaction with ATF4.

Author information

1
Key Lab of Physiology, Biochemistry & Molecular Biology of Hebei Province, Hebei Normal University, Shijiazhuang 050024, China; State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing 100094, China.
2
State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing 100094, China.
3
Key Lab of Physiology, Biochemistry & Molecular Biology of Hebei Province, Hebei Normal University, Shijiazhuang 050024, China.
4
Key Lab of Physiology, Biochemistry & Molecular Biology of Hebei Province, Hebei Normal University, Shijiazhuang 050024, China. Electronic address: chang7676@163.com.
5
State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing 100094, China. Electronic address: yingxianli@aliyun.com.

Abstract

Histone deacetylase 4 (HDAC4) is involved in the regulation of many fundamental cell processes such as proliferation, differentiation, and survival via the modification of their substrates or protein-protein interactions. In this study, we found that HDAC4 could be upregulated under ER stress. There exists a direct interaction between HDAC4 and activating transcription factor 4 (ATF4). In vitro, overexpression of HDAC4 caused the retention of ATF4 in cytoplasm and inhibition of ATF4 transcriptional activity. ER stress could promote cell apoptosis through the upregulation of ATF4 levels and its target genes such as CHOP and TRB3. This effect was exacerbated by downregulation of HDAC4 levels. These results demonstrated that HDAC4 played an important role in the regulation of ER stress-induced apoptosis through interacting with ATF4 and inhibiting its transcriptional activity.

KEYWORDS:

ATF4; Cell apoptosis; Endoplasmic reticulum stress; HDAC4

PMID:
24308964
DOI:
10.1016/j.cellsig.2013.11.026
[Indexed for MEDLINE]

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