Format

Send to

Choose Destination
Strahlenther Onkol. 2014 Feb;190(2):223-8. doi: 10.1007/s00066-013-0470-7. Epub 2013 Dec 6.

Whole abdominopelvic radiotherapy in the palliative treatment of pseudomyxoma peritonei.

Author information

1
Department of Radiotherapy, Ghent University Hospital, De Pintelaan 185, 9000, Ghent, Belgium, Patrick.Berkovic@uzgent.be.

Abstract

BACKGROUND:

Pseudomyxoma peritonei (PMP) is a rare clinical syndrome characterized by mucinous peritoneal disease arising from disseminated peritoneal adenomucinosis. Primary treatment involves a combination of cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC). There is no consensus on the proper treatment of recurrent PMP. In selected patients, repeated cytoreductive surgery with or without HIPEC might improve outcome. However, every repeated debulking procedure becomes less effective with increased morbidity.

CASE REPORT:

We present a case of a patient with intestinal obstruction caused by recurrent pseudomyxoma peritonei. We treated the patient with whole abdominopelvic radiotherapy (WAPRT) using intensity-modulated arc therapy (IMAT) to a total dose of 33 Gy, delivered in 22 daily fractions. The treatment was well tolerated and resulted in resolution of the obstruction for a period of 24 months.

CONCLUSION:

To the best of our knowledge, we present the first case report showing the possibility of resolving intestinal obstruction with WAPRT in a patient with recurrent PMP. It is our opinion that WAPRT delivered by IMAT, in analogy with ovarian cancer, should be considered as a palliative treatment option in managing patients with recurrent PMP especially in case of obstruction.

PMID:
24306063
DOI:
10.1007/s00066-013-0470-7
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center