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Nat Struct Mol Biol. 2013 Dec;20(12):1348-50. doi: 10.1038/nsmb.2727.

PrimPol breaks replication barriers.

Author information

1
Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.

Abstract

Faithful bypass of replication forks encountering obstructive DNA lesions is essential to prevent fork collapse and cell death. PrimPol is a new human primase and translesion polymerase that is able to bypass fork-blocking UV-induced lesions and to restart replication by origin-independent repriming.

PMID:
24304914
DOI:
10.1038/nsmb.2727
[Indexed for MEDLINE]

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