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Nat Struct Mol Biol. 2013 Dec;20(12):1344-6. doi: 10.1038/nsmb.2728.

Poly-combing the genome for RNA.

Author information

  • 1Stem Cell and Regenerative Biology Department, Harvard University, Cambridge, Massachusetts, USA, and the Broad Institute, Cambridge, Massachusetts, USA.

Abstract

An unresolved question in mammalian epigenetic regulation is how ubiquitously expressed chromatin-modifying complexes such as Polycomb group complex 2 (PRC2) find their specific target sites across an intricate choreography of localization events in time and space. Two recent studies now provide critical new insights into an intriguing genome-wide role for RNA in PRC2 regulation.

PMID:
24304912
DOI:
10.1038/nsmb.2728
[PubMed - indexed for MEDLINE]
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