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Nucleic Acids Res. 2014 Jan;42(Database issue):D737-43. doi: 10.1093/nar/gkt1252. Epub 2013 Dec 3.

BacMet: antibacterial biocide and metal resistance genes database.

Author information

1
Department of Infectious Diseases, Institute of Biomedicine, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, SE-413 46, Sweden, Department of Plant and Environmental Sciences, University of Copenhagen, Copenhagen, DK-1871, Denmark and Department of Mathematical Sciences, Chalmers University of Technology, SE-412 96, Gothenburg, Sweden.

Abstract

Antibiotic resistance has become a major human health concern due to widespread use, misuse and overuse of antibiotics. In addition to antibiotics, antibacterial biocides and metals can contribute to the development and maintenance of antibiotic resistance in bacterial communities through co-selection. Information on metal and biocide resistance genes, including their sequences and molecular functions, is, however, scattered. Here, we introduce BacMet (http://bacmet.biomedicine.gu.se)--a manually curated database of antibacterial biocide- and metal-resistance genes based on an in-depth review of the scientific literature. The BacMet database contains 470 experimentally verified resistance genes. In addition, the database also contains 25 477 potential resistance genes collected from public sequence repositories. All resistance genes in the BacMet database have been organized according to their molecular function and induced resistance phenotype.

PMID:
24304895
PMCID:
PMC3965030
DOI:
10.1093/nar/gkt1252
[Indexed for MEDLINE]
Free PMC Article

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