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Nucleic Acids Res. 2014 Jan;42(Database issue):D78-85. doi: 10.1093/nar/gkt1266. Epub 2013 Dec 4.

miRTarBase update 2014: an information resource for experimentally validated miRNA-target interactions.

Author information

1
Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu 300, Taiwan, Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung 402, Taiwan, Department of Computer Science and Engineering, National Chung Hsing University, Taichung 402, Taiwan, Department of Biological Science and Technology, National Chiao Tung University, Hsinchu 300, Taiwan, Molecular Bioinformatics Center, National Chiao Tung University, Hsinchu 300, Taiwan, Graduate Department of Clinical Pharmacy, Taipei Medical University, Taipei 110, Taiwan, Institute of Molecular Medicine and Bioengineering, National Chiao Tung University, Hsinchu 300, Taiwan, Graduate Institute of Biomedical Informatics, Taipei Medical University, Taipei 110, Taiwan, Department of Obstetrics and Gynecology, Hsinchu Mackay Memorial Hospital, Hsinchu 300, Taiwan, Mackay Medicine, Nursing and Management College, Taipei 112, Taiwan, Department of Medicine, Mackay Medical College, New Taipei City 252, Taiwan, and Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung 807, Taiwan.

Abstract

MicroRNAs (miRNAs) are small non-coding RNA molecules capable of negatively regulating gene expression to control many cellular mechanisms. The miRTarBase database (http://mirtarbase.mbc.nctu.edu.tw/) provides the most current and comprehensive information of experimentally validated miRNA-target interactions. The database was launched in 2010 with data sources for >100 published studies in the identification of miRNA targets, molecular networks of miRNA targets and systems biology, and the current release (2013, version 4) includes significant expansions and enhancements over the initial release (2010, version 1). This article reports the current status of and recent improvements to the database, including (i) a 14-fold increase to miRNA-target interaction entries, (ii) a miRNA-target network, (iii) expression profile of miRNA and its target gene, (iv) miRNA target-associated diseases and (v) additional utilities including an upgrade reminder and an error reporting/user feedback system.

PMID:
24304892
PMCID:
PMC3965058
DOI:
10.1093/nar/gkt1266
[Indexed for MEDLINE]
Free PMC Article

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