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Kidney Int. 2014 Jul;86(1):146-53. doi: 10.1038/ki.2013.470. Epub 2013 Dec 4.

Subclinical cardiovascular disease is associated with a high glomerular filtration rate in the nondiabetic general population.

Author information

1
1] Department of Clinical Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway [2] Section of Nephrology, University Hospital of North Norway, Tromsø, Norway [3] Department of Clinical Research, University Hospital of North Norway, Tromsø, Norway.
2
Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway.
3
1] Department of Clinical Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway [2] Department of Neurology and Neurophysiology, University Hospital of North Norway, Tromsø, Norway.
4
1] Department of Clinical Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway [2] Department of Ophthalmology, University Hospital of North Norway, Tromsø, Norway.
5
Department of Clinical Research, University Hospital of North Norway, Tromsø, Norway.
6
1] Department of Clinical Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway [2] Department of Ophthalmology, Nordland Hospital, Bodø, Norway.
7
1] Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway [2] Department of Radiology, University Hospital of North Norway, Tromsø, Norway.
8
1] Department of Clinical Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway [2] Department of Nephrology, Oslo University Hospital, Oslo, Norway.
9
Section of Nephrology, University Hospital of North Norway, Tromsø, Norway.
10
1] Department of Clinical Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway [2] Section of Nephrology, University Hospital of North Norway, Tromsø, Norway.

Abstract

A reduced glomerular filtration rate (GFR) in chronic kidney disease is a risk factor for cardiovascular disease. However, evidence indicates that a high GFR may also be a cardiovascular risk factor. This issue remains unresolved due to a lack of longitudinal studies of manifest cardiovascular disease with precise GFR measurements. Here, we performed a cross-sectional study of the relationship between high GFR measured as iohexol clearance and subclinical cardiovascular disease in the Renal Iohexol Clearance Survey in Tromsø 6 (RENIS-T6), a representative sample of the middle-aged general population. A total of 1521 persons without cardiovascular disease, chronic kidney disease, diabetes, or micro- or macroalbuminuria were examined with carotid ultrasonography and electrocardiography. The GFR in the highest quartile was associated with an increased odds ratio of having total carotid plaque area greater than the median of non-zero values (odds ratio 1.56, 95% confidence interval 1.02-2.39) or electrocardiographic signs of left ventricular hypertrophy (odds ratio 1.62, 95% confidence interval 1.10-2.38) compared to the lowest quartile. The analyses were adjusted for cardiovascular risk factors, urinary albumin excretion, and fasting serum glucose. Thus, high GFR is associated with carotid atherosclerosis and left ventricular hypertrophy and should be investigated as a possible risk factor for manifest cardiovascular disease in longitudinal studies.

PMID:
24304885
DOI:
10.1038/ki.2013.470
[Indexed for MEDLINE]
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