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Molecules. 2013 Dec 4;18(12):14892-919. doi: 10.3390/molecules181214892.

C-4 gem-dimethylated oleanes of Gymnema sylvestre and their pharmacological activities.

Author information

1
Department of Chemical Sciences, University Federico II, Complesso Universitario Monte S. Angelo, Via Cintia 4, Napoli 80126, Italy. zarrelli@unina.it.

Abstract

Gymnema sylvestre R. Br., one of the most important medicinal plants of the Asclepiadaceae family, is a herb distributed throughout the World, predominantly in tropical countries. The plant, widely used for the treatment of diabetes and as a diuretic in Indian proprietary medicines, possesses beneficial digestive, anti-inflammatory, hypoglycemic and anti-helmentic effects. Furthermore, it is believed to be useful in the treatment of dyspepsia, constipation, jaundice, hemorrhoids, cardiopathy, asthma, bronchitis and leucoderma. A literature survey revealed that some other notable pharmacological activities of the plant such as anti-obesity, hypolipidemic, antimicrobial, free radical scavenging and anti-inflammatory properties have been proven too. This paper aims to summarize the chemical and pharmacological reports on a large group of C-4 gem-dimethylated pentacyclic triterpenoids from Gymnema sylvestre.

PMID:
24304585
PMCID:
PMC6269971
DOI:
10.3390/molecules181214892
[Indexed for MEDLINE]
Free PMC Article

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