Format

Send to

Choose Destination
Physiol Rep. 2013 Jun;1(1):e00008. doi: 10.1002/PHY2.8. Epub 2013 Jun 7.

Elevated pulmonary arterial pressure and altered expression of Ddah1 and Arg1 in mice lacking cavin-1/PTRF.

Author information

1
Department of Experimental Medical Science, Biomedical Centre, Lund University BMC D12, SE-221 84, Lund, Sweden.

Abstract

Caveolae are invaginations in the plasma membrane that depend on caveolins and cavins for maturation. Here, we investigated the pulmonary phenotype in mice lacking cavin-1. Bright field and electron-microscopy showed that the cavin-1-deficient mice lacked caveolae in the lung, had an increased lung tissue density, and exhibited hypertrophic remodeling of pulmonary arteries. The right ventricle of the heart moreover had an increased mass and the right ventricular pressure was elevated. A microarray analysis revealed upregulation of Arg1 and downregulation of Ddah1, molecules whose altered expression has previously been associated with pulmonary arterial hypertension. Taken together, this work demonstrates vascular remodeling and increased pulmonary blood pressure in cavin-1 deficient mice and associates this phenotype with altered expression of Arg1 and Ddah1.

KEYWORDS:

Bmp4; Foxc2; Lpin1; caveolin; nitric oxide; plau

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center