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Pediatr Obes. 2014 Jun;9(3):e73-6. doi: 10.1111/j.2047-6310.2013.00206.x. Epub 2013 Dec 2.

Inverse relationship between gestational weight gain and glucose uptake in human placenta from female foetuses.

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1
Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne, Heidelberg, Victoria, Australia.

Abstract

BACKGROUND:

Maternal obesity and gestational weight gain (GWG) have a significant impact on the in utero environment, and thus on foetal development and the health of the offspring later in life.

OBJECTIVE:

The aim of this study was to determine the effect of maternal pre-existing obesity and maternal GWG on glucose uptake from placentas from male and female offspring.

METHODS:

Total glucose uptake was measured in placental explants using radio-labelled glucose.

RESULTS:

In the female placentas (n = 36), GWG and glucose uptake were significantly negatively correlated (r = -0.7, P < 0.0001; n = 36), and customized birthweight centile correlated with placental glucose uptake (r = 0.36, P = 0.03) but not GWG. In the male placentas (n = 45), GWG and glucose uptake were not related, and customized birthweight centile correlated with GWG (r = 0.34, P = 0.02; n = 45), but not placental glucose uptake.

CONCLUSIONS:

The female placenta can adapt glucose uptake in the face of excessive GWG. The male placenta showed no evidence of changing glucose uptake in response to maternal GWG.

KEYWORDS:

Foetal gender; glucose uptake; maternal gestational weight gain; placenta

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