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Chem Commun (Camb). 2014 Jan 28;50(8):951-3. doi: 10.1039/c3cc48067d.

Highly diastereoselective synthesis of 3-hydroxy-2,2,3-trisubstituted indolines via intramolecular trapping of ammonium ylides with ketones.

Author information

1
Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, East China Normal University, Shanghai, 200062, China. whu@chem.ecnu.edu.cn.

Abstract

A Rh2(OAc)4-catalyzed diazo decomposition reaction of diazo esters with 2-aminophenyl ketones is reported. A series of 3-hydroxy-2,2,3-trisubstituted indolines are produced in good yields with excellent diastereoselectivities via an intramolecular aldol-type trapping of ammonium ylides with ketone units.

PMID:
24302029
DOI:
10.1039/c3cc48067d
[Indexed for MEDLINE]

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