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Chem Commun (Camb). 2014 Jan 28;50(8):975-7. doi: 10.1039/c3cc47922f.

The promotion of antimicrobial activity on silicon substrates using a "click" immobilized short peptide.

Author information

  • 1National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510006, China. imwangyj@163.com.

Abstract

We demonstrated, for the first time, that the short antimicrobial peptide Tet213 could be conjugated onto the silicon surface by Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC). The modified surface exhibited excellent antimicrobial activity against S. aureus and E. coli, and low cytotoxicity to rat bone mesenchymal stem cells (rBMSCs).

PMID:
24301818
DOI:
10.1039/c3cc47922f
[PubMed - indexed for MEDLINE]
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