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Evolution. 2013 Dec;67(12):3512-22. doi: 10.1111/evo.12207. Epub 2013 Aug 2.

Shifting fitness landscapes in response to altered environments.

Author information

1
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
2
School of Life Sciences, École Polytechnique Fédérale de Lausanne, Switzerland.
3
Swiss Institute of Bioinformatics (SIB).
#
Contributed equally

Abstract

The role of adaptation in molecular evolution has been contentious for decades. Here, we shed light on the adaptive potential in Saccharomyces cerevisiae by presenting systematic fitness measurements for all possible point mutations in a region of Hsp90 under four environmental conditions. Under elevated salinity, we observe numerous beneficial mutations with growth advantages up to 7% relative to the wild type. All of these beneficial mutations were observed to be associated with high costs of adaptation. We thus demonstrate that an essential protein can harbor adaptive potential upon an environmental challenge, and report a remarkable fit of the data to a version of Fisher's geometric model that focuses on the fitness trade-offs between mutations in different environments.

KEYWORDS:

Adaptation; Fisher's geometric model; adaptive walk; distribution of fitness effects; experimental evolution

PMID:
24299404
PMCID:
PMC3855258
DOI:
10.1111/evo.12207
[Indexed for MEDLINE]
Free PMC Article

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