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Philos Trans R Soc Lond B Biol Sci. 2013 Dec 2;369(1633):20130131. doi: 10.1098/rstb.2013.0131. Print 2014 Jan 5.

NMDA receptor-dependent long-term potentiation comprises a family of temporally overlapping forms of synaptic plasticity that are induced by different patterns of stimulation.

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Department of Brain and Cognitive Sciences, College of Natural Sciences, Seoul National University, , Seoul 151-746, South Korea.


N-methyl-d-aspartate receptor (NMDAR)-dependent long-term potentiation (LTP) is extensively studied since it is believed to use the same molecular mechanisms that are required for many forms of learning and memory. Unfortunately, many controversies exist, not least the seemingly simple issue concerning the locus of expression of LTP. Here, we review our recent work and some of the extensive literature on this topic and present new data that collectively suggest that LTP can be explained, during its first few hours, by the coexistence of at least three mechanistically distinct processes that are all triggered by the synaptic activation of NMDARs.


AMPA receptor; NMDA receptor; hippocampus; learning and memory; long-term potentiation; short-term potentiation

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