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J Am Soc Mass Spectrom. 2014 Mar;25(3):303-9. doi: 10.1007/s13361-013-0777-8. Epub 2013 Dec 3.

Advantages of monodisperse and chemically robust "SpheriCal" polyester dendrimers as a "universal" MS calibrant.

Author information

1
Department of Chemistry, Tulane University, New Orleans, LA, 70118, USA, sgrayson@tulane.edu.

Abstract

The utilization of dendrimer calibrants as an alternative to peptides and proteins for high mass calibration is explored. These synthetic macromolecules exhibited a number of attractive advantages, including exceptional shelf-lives, broad compatibility with a wide range of matrices and solvents, and evenly spaced calibration masses across the mass range examined, 700-30,000 u. The exceptional purity of these dendrimers and the technical simplicity of this calibration platform validate their broad relevance for high molecular weight mass spectrometry.

PMID:
24297473
DOI:
10.1007/s13361-013-0777-8
[Indexed for MEDLINE]

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