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Int J Biol Macromol. 2014 Mar;64:25-9. doi: 10.1016/j.ijbiomac.2013.11.016. Epub 2013 Dec 1.

Effect of orally administered hydroxypropyl chitosan on the levels of iron, copper, zinc and calcium in mice.

Author information

1
Hubei Key Laboratory of Biomass-Resource Chemistry and Environmental Biotechnology, Hubei Engineering University, Xiaogan 432000, China; Hubei Key Laboratory of Quality Control of Characteristic Fruits and Vegetables, Hubei Engineering University, Xiaogan, Hubei 432000, China.
2
Hubei Key Laboratory of Biomass-Resource Chemistry and Environmental Biotechnology, Hubei Engineering University, Xiaogan 432000, China.
3
Hubei Key Laboratory of Quality Control of Characteristic Fruits and Vegetables, Hubei Engineering University, Xiaogan, Hubei 432000, China.
4
Hubei Key Laboratory of Biomass-Resource Chemistry and Environmental Biotechnology, Hubei Engineering University, Xiaogan 432000, China. Electronic address: qincq@hbeu.edu.cn.

Abstract

Two hydroxypropyl chitosan HPCS samples (HPCS1 Mw 1.6 × 10(5), HPCS2 Mw 3.5 × 10(4)) were prepared by the reaction of chitosan with propylene oxide under alkali conditions. The median lethal dose of the hydroxypropyl chitosan was greater than 10 g/kg for the laboratory mice. HPCS1 at the 0.1%, 1.0%, 1.5% and HPCS2 at the 1.0% level in diets were used to feed the mice for 90 days respectively. No pathological symptoms, clinical signs or deaths were observed for all mice. The weights of the mice in HPCS groups and control group had no significant difference. The levels of Fe, Cu, Zn and Ca in the mice were measured by atomic absorption spectrophotometry. HPCS had no significant effect on the levels of Fe, Cu, Zn and Ca in the tested mice's livers and hearts. However, hydroxypropyl chitosan at high dose exhibited inhibitory effects on the levels of Fe, Zn and Ca in some organizations.

KEYWORDS:

Hydroxypropyl chitosan; Metal element; Mouse

PMID:
24296411
DOI:
10.1016/j.ijbiomac.2013.11.016
[Indexed for MEDLINE]
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