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J Proteome Res. 2014 Feb 7;13(2):1143-6. doi: 10.1021/pr4008078. Epub 2014 Jan 7.

DeNovoGUI: an open source graphical user interface for de novo sequencing of tandem mass spectra.

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1
Max Planck Institute for Dynamics of Complex Technical Systems , Sandtorstraße 1, 39106 Magdeburg, Germany.

Abstract

De novo sequencing is a popular technique in proteomics for identifying peptides from tandem mass spectra without having to rely on a protein sequence database. Despite the strong potential of de novo sequencing algorithms, their adoption threshold remains quite high. We here present a user-friendly and lightweight graphical user interface called DeNovoGUI for running parallelized versions of the freely available de novo sequencing software PepNovo+, greatly simplifying the use of de novo sequencing in proteomics. Our platform-independent software is freely available under the permissible Apache2 open source license. Source code, binaries, and additional documentation are available at http://denovogui.googlecode.com .

PMID:
24295440
PMCID:
PMC3923451
DOI:
10.1021/pr4008078
[Indexed for MEDLINE]
Free PMC Article
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