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ACS Appl Mater Interfaces. 2013 Dec 26;5(24):13063-8. doi: 10.1021/am404042r. Epub 2013 Dec 11.

A detailed investigation on the interactions between magnetic nanoparticles and cell membrane models.

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Nanomedicine and Nanotoxicology Group, Physics Institute of São Carlos, University of São Paulo , CP 369, São Carlos, São Paulo, Brazil 13566-590.


The understanding of the interactions between small molecules and magnetic nanoparticles is of great importance for many areas of bioapplications. Although a large array of studies in this area have been performed, aspects involving the interaction of magnetic nanoparticles with phospholipids monolayers, which can better mimic biological membranes, have not yet been clarified. This study was aimed at investigating the interactions between Langmuir films of dipalmitoyl phosphatidylglycerol and dipalmitoyl phosphatidylcholine, obtained on an aqueous subphase, and magnetic nanoparticles. Sum-frequency generation (SFG) vibrational spectroscopy was used to verify the orientation and molecular conformation and to better understand the interactions between phospholipids and the magnetic nanoparticles. Surface pressure-area isotherms and SFG spectroscopy made it possible to investigate the interaction of these nanomaterials with components of phospholipids membranes at the water surface.


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