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Mol Pharm. 2014 Jan 6;11(1):276-82. doi: 10.1021/mp400448w. Epub 2013 Dec 9.

Multilayered polymer-coated carbon nanotubes to deliver dasatinib.

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1
Department of Bioengineering, Clemson University , Clemson, South Carolina 29634, United States.

Abstract

Multilayered, multifunctional polymer coatings were grafted onto carbon nanotubes (CNTs) using a one-pot, ring-opening polymerization in order to control the release kinetic and therapeutic efficacy of dasatinib. Biocompatible, biodegradable multilayered coatings composed of poly(glycolide) (PGA) and poly(lactide) (PLA) were polymerized directly onto hydroxyl-functionalized CNT surfaces. Sequential addition of monomers into the reaction vessel enabled multilayered coatings of PLA-PGA or PGA-PLA. Poly(ethylene glycol) capped the polymer chain ends, resulting in a multifunctional amphiphilic coating. Multilayer polymer coatings on CNTs enabled control of the anticancer drug dasatinib's release kinetics and enhanced the in vitro therapeutic efficacy against U-87 glioblastoma compared to monolayer polymer coatings.

PMID:
24294824
PMCID:
PMC4065492
DOI:
10.1021/mp400448w
[Indexed for MEDLINE]
Free PMC Article
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